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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

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By John Furness, Kara Britt, Brid Callaghan, Giorgio G. Inghirami, Yufeng Wang, Xin Huang, Jason Spector, Eleni Andreopoulou, Paul Zumbo, Lukas Dow, Kristy A. Brown, Sofya Oshchepkova, Heta Ladumor, Kai Ying Soo, Celine Gerard, Vivek Mittal, Doron Betel
| eLife
Abstract Breast cancer is the most common type of cancer in women and notwithstanding important therapeutic advances, remains the second leading cause of cancer-related death. Despite extensive research relating to the hormone ghrelin, responsible for the stimulation of growth hormone release and appetite, little is known of the effects of its unacylated form, especially in cancer.
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