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Kaideya Wushaying on Muck Rack

Kaideya Wushaying

As seen in: Nature
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Phosphorylation of IRS4 at YY111/112 promotes LUSC progression via PI3K/AKT pathway activation

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By Xiangling Jiang, Ran Chen, Yanli Wang, Xian Zhao, Lei Xu, Zhi Yang, Jianxiu Yu, Jian Huang, Yilixiati Aihemaiti, Qiuhan Ren, Kaideya Wushaying
| Nature Verified
Abstract Lung squamous cell carcinoma (LUSC) lacks effective targeted therapies despite frequent hyperactivation of the PI3K/AKT pathway, and the contribution of adaptor proteins to this process remains poorly defined. Here, we identify Insulin Receptor Substrate 4 (IRS4) as a common substrate of Src kinase and the phosphatase RPTPα, and uncover a previously unrecognized, conserved phosphorylation site at YY111/112 within the IRS4 PH domain.
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