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Kailen Mark on Muck Rack

Kailen Mark

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Selective targeting of RSK signaling with PMD-026 suppresses FLT3-activated acute myeloid leukemia while sparing normal hematopoiesis

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By Gavin M. Traber, Hee-Don Chae, Minyoung Youn, Sandra Dunn, Kathleen M. Sakamoto, Kailen Mark, Aarthi Jayanthan, Jenny Youm
| Nature Verified
To the editor: Acute myeloid leukemia (AML) is a molecularly heterogeneous and aggressive hematologic malignancy and is characterized by the clonal expansion of immature myeloid progenitor cells within the bone marrow, peripheral blood, and extramedullary tissues [1]. Despite recent advances in molecular profiling, AML remains associated with poor long-term outcomes and a low 5-year overall survival of approximately 30% in adults [1, 2].
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