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Kaina Chen

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Articles by Kaina Chen

The International Chinese Young Scholars Alliance for the Study of the Liver: facilitating global collaboration

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By Wenhao Li, Zhujun Cao, Ying Shang, Kaina Chen, Xiaolong Qi
| Nature Verified
The global profile of Chinese hepatology has expanded rapidly over the past four decades, driven by major scientific investment, increased global mobility and landmark clinical and translational discoveries. As a new generation of Chinese investigators emerges around the globe, initiatives that foster international collaboration, mentorship and scientific exchange will be essential for advancing the future of global liver research.
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The association between tumour heterogeneity and immune evasion mechanisms in hepatocellular carcinoma and its clinical implications - British Journal of Cancer

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By Kaina Chen
| Nature Verified
Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. The emergence of combination therapy, atezolizumab (anti-PDL1, immune checkpoint inhibitor) and bevacizumab (anti-VEGF) has revolutionised the management of HCC. Despite this breakthrough, the best overall response rate with first-line systemic therapy is only about 30%, owing to intra-tumoural heterogeneity, complex tumour microenvironment and the lack of predictive biomarkers.
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