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Kaito Nakata

As seen in: BioRxiv
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Articles

Amyloid-β-induced Alteration of Fast and Localized Calcium Elevations in Cultured Astrocytes

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By Joe Sakamoto, Kohei Otomo, Kaito Nakata, Masanao Sato
| BioRxiv
Abstract Alzheimer′s disease (AD) is a progressive neurodegenerative disorder that causes cognitive decline. Uncovering the mechanisms of neurodegeneration in the early stages is essential to establish a treatment for AD. Recent research has proposed the hypothesis that amyloid-β (Aβ) oligomers elicit an excessive glutamate release from astrocytes toward synapses through intracellular free Ca2+ ([Ca2+]i) elevations in astrocytes, finally resulting in neuronal dendritic spine loss.
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