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Kaitriana E. Colling on Muck Rack

Kaitriana E. Colling

As seen in: BioRxiv
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Articles

Multiplexed live-cell imaging for drug responses in patient-derived organoid models of cancer

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By Lorenzo Buroni, Kaitriana E. Colling, Emily L. Symons, Hiruni K. Sumanasiri
| BioRxiv
Abstract Patient-derived organoid (PDO) models of cancer are a multifunctional research system that better recapitulates human disease as compared to cancer cell lines. PDO models can be generated by culturing patient tumor cells in extracellular basement membrane extracts (BME) and plating as three-dimensional domes. However, commercially available reagents that have been optimized for phenotypic assays in monolayer cultures often are not compatible with BME.
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