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Kaj Fried

Stockholm
As seen in: Nature, Cell Press
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Articles by Kaj Fried

Atlas of cell types and regulatory elements underlying human facial diversity

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By Alek G. Erickson, Yaakov Gershtein, Rozalina Galimullina, Markéta Kaiser, Daniela Schnyder, Lei Li, Aliia Murtazina, Sergey Isaev, Thibault Bouderlique, Hugo Zeberg, Tomas Zikmund, Jozef Kaiser, Kaj Fried, Elena I Shagimardanova, Leyla H. Shigapova, Guzel R. Gazizova, Ruslan Deviatiiarov, Seppe Goovaerts, Yuk Kit Lor, Gonçalo Castelo-Branco, Peter Claes, Xiaofei Li, Oleg Gusev, Andrei S Chagin, Erik Sundström, Peter V. Kharchenko, Igor Adameyko, Felix Waern, Tonyak Riba, Nikita Vaulin, Saga Samuelsson, Viktoria Parobkova, Ivan V. Reva, Kateřina Vymazalová
| Nature Verified
Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we created a multimodal facial atlas across embryonic weeks 6–11, providing single-cell transcriptomics, chromatin accessibility and spatial transcriptomics, all at single-cell resolution.
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Motor innervation directs the correct development of the mouse sympathetic nervous system - Nature Communications

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By Alek G. Erickson, Alessia Motta, Maria Eleni Kastriti, Giovanni Canu, Francois Lallemend, Saida Hadjab, Kaj Fried, Christiana Ruhrberg, Quenten Schwarz, Valerie Castellani, Dario Bonanomi, Aliia Murtazina, Irina Poverennaya, Jeremy Ganofsky
| Nature Verified
Abstract The sympathetic nervous system controls bodily functions including vascular tone, cardiac rhythm, and the “fight-or-flight response”. Sympathetic chain ganglia develop in parallel with preganglionic motor nerves extending from the neural tube, raising the question of whether axon targeting contributes to sympathetic chain formation.
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The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling - Nature Communications

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By Meng Xie, Daniela Schnyder, Ruslan Deviatiiarov, Tomas Zikmund, Dominyka Batkovskyte, Phillip T. Newton, Olov Andersson, Kaj Fried, Hugo Zeberg, Jozef Kaiser, Igor Adameyko, Markéta Kaiser
| Nature Verified
Abstract The development of craniofacial skeletal structures is fascinatingly complex and elucidation of the underlying mechanisms will not only provide novel scientific insights, but also help develop more effective clinical approaches to the treatment and/or prevention of the numerous congenital craniofacial malformations.
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Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology | Nature Communications

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By Julian Petersen, Lukas Englmaier, Markéta Tesařová, Ruslan Deviatiiarov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, David Potesil, Anna Grabowski, Miriam E. Buhl, Tomas Zikmund, Michaela Kavkova, Christoph Kuppe, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Jan Prochazka, Radislav Sedlacek, Vitezslav Bryja
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-023-38663-7 published online 29 May 2023 The original version of this Article incorrectly listed Prof. Oleg Gusev as being affiliated with “Endocrinology Research Center, Moscow, Russia” and “Center for Integrative Medical Sciences, RIKEN, Yokohama City, Kanagawa, Japan”. The aforementioned affiliations have now been removed and the following was added for Prof.
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A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology | Nature Communications

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By Julian Petersen, Lukas Englmaier, Markéta Tesařová, Ruslan Deviatiiarov, David Pajuelo Reguera, Hugo Zeberg, Marketa Kaucka, Jan Krivanek, Tomasz Radaszkiewicz, Kristína Gömöryová, David Potesil, Anna Grabowski, Tomas Zikmund, Christoph Kuppe, Tibor Harkany, Kaj Fried, Jozef Kaiser, Peter Boor, Csaba Fekete, Jan Rozman, Jan Prochazka, Radislav Sedlacek, Miriam E. Buhl, Michaela Kavkova, Vitezslav Bryja
| Nature Verified
Statement on ethical considerations All animal work was approved and permitted by the Local Ethical Committee on Animal Experiments and conducted according to the Guidelines for Animal Experimentation recommendations (ARRIVE guidelines). In particular, mouse work related to C57BL/6NCrl mice was approved and permitted by the Institute of Molecular Genetics of the Czech Academy of Sciences (licence: 45/2017 AVCR).
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Directionality of developing skeletal muscles is set by mechanical forces - Nature Communications

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By Delf Kah, Ben Fabry, Louis Faure, Shigeaki Kanatani, Marketa Kaucka, Markéta Tesařová, Tomas Zikmund, Jozef Kaiser, Taiji Adachi, Kaj Fried
| Nature Verified
Abstract Formation of oriented myofibrils is a key event in musculoskeletal development. However, the mechanisms that drive myocyte orientation and fusion to control muscle directionality in adults remain enigmatic. Here, we demonstrate that the developing skeleton instructs the directional outgrowth of skeletal muscle and other soft tissues during limb and facial morphogenesis in zebrafish and mouse.
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