Kaleb J. Tyson on Muck Rack

Kaleb J. Tyson

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Articles

Diabetes potentiates the emergence and expansion of antibiotic resistance

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By Hui-bo Tang, So-Won Park, Cindy Gutzeit, John Shook, Christopher J. Genito, Amanda Z Velez, Joshua Parsons, Sarah Rowe, Christopher W. Marshall, Brian Conlon, Lance R. Thurlow, Benjamin P. Darwitz, Kaleb J. Tyson, Sophia K. Bridwell
| Science Magazine Verified
Abstract Individuals with diabetes mellitus frequently develop severe skin and soft tissue infections (SSTIs) that are recalcitrant to antibiotic treatment. We examined how diabetes affects the emergence of antibiotic resistance in a Staphylococcus aureus SSTI. We determined that S. aureus evolves antibiotic resistance rapidly in diabetic mice, while resistance did not occur in nondiabetic mice over the course of infection.
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