Kamilla Kjærgaard Munk on Muck Rack

Kamilla Kjærgaard Munk

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Articles

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy - Nature Communications

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By Tao Zheng, Keerthana Ramanathan, Hanxi Li, Carlos Rodriguez-Pardo, Klaus Qvortrup, Yi Sun, Kamilla Kjærgaard Munk
| Nature Verified
Abstract Adoptive T cell therapy using chimeric antigen receptor (CAR) engineered T cells is currently being explored in multiple cancer types beyond leukemia/lymphoma. A key step in CAR-T cell manufacturing is the activation and expansion of T cells, which facilitates viral transduction, however, may hamper T cell fitness and reduce in vivo persistence.
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