KEY WORDS Obscurin actin cell migration confocal microscopy PIP3 cancer EMT metastasis ABRREVIATIONS BirA (Biotin inregulatory activity protein) EMT (Epithelial to Mesenchymal Transition) MDCK (Madin-Darby Canine Kidney cell line) MCF-10A (non-tumorigenic human mammary epithelial cell line) ObscA (Obscurin A C-terminus residues 1-110+6561-7496) ObscN (Obscurin N terminus residues 1-1406) PH (Pleckstrin Homology domain) PI(3)K-PIP3 Kinase (PIP3) Phosphatidylinositol-(3,4,5)-triphosphate (RhoA-...