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Selective Proximal Renal Denervation Guided by Autonomic Responses Evoked via High-Frequency Stimulation in a Preclinical Canine Model

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By Chang Liu, Tingquan Zhou, Zhenglong Wang, Shaojie Chen, Zhen Tan, Hanxuan Yang, Jiayi Lu, Weijie Chen, Huaan Du, Xinyu Hu, Zhiyu Ling, Zengzhang Liu, Bernhard Zrenner, Kamsang Woo
| circinterventions.ahajournals.org
Methods and Results—A total of 13 Chinese Kunming dogs were included and allocated to proximal RDN group (n=8) and control group (n=5). HFS (20 Hz, 8 V, pulse width 2 ms) was performed from proximal to distal renal artery in all dogs. Radiofrequency ablations were delivered in proximal RDN group and only at the proximal positive sites where systolic blood pressure (BP) increased ≥10 mm Hg during HFS. Postablation HFS was performed over the previously stimulated sites.
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