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Kanat Yalcin on Muck Rack

Kanat Yalcin

As seen in: BioRxiv
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Articles

Non-invasive approach for endoluminal biopsy coupled with single-cell proteomics allows for immune characterization of intracranial aneurysms

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By Joseph K. Antonios, Brianna C. Theriault, Batur Gultekin, Kanat Yalcin
| BioRxiv
Abstract The immune regulatory mechanisms driving the stability, growth, and rupture of intracranial aneurysms (IAs) remain incompletely understood. In this study, we employ endoluminal biopsy with single-cell proteomics to comprehensively profile the immune landscape of IAs across their pathologic states. Our findings reveal distinct immune signatures associated with aneurysm states. Stable, i.e. non-growing unruptured, IAs exhibit a balanced immune cell composition.
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