Kang-Fu Yin

We appreciate the attention and feedback from Liu et al. [1] on our study. We highly value their comments and would like to address some misunderstandings and provide additional background information through the following points. Firstly, Liu et al. mentioned that colocalisation analysis following Mendelian randomisation (MR) analysis might introduce irrelevant pleiotropic effects by violating the exclusion restriction assumption, thereby not strengthening the MR results.

Introduction Sarcopenia has been recognized as a muscle disease, characterized by age-related loss of muscle mass and function.1 According to the definition of the European Working Group on Sarcopenia in Older People (EWGSOP), 4.6% of men and 7.9% of women with an average age of 67 suffer from sarcopenia.2 It is a major cause of frailty, functional decline, increased risk of falls, and premature death in the elderly, all imposing a heavy burden on the healthcare system.3 Lifestyle measures,...