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Kantarou Sahara on Muck Rack

Kantarou Sahara

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Articles

Transcriptomic analysis defines gestation-specific programs of fetal liver maturation in premature sheep

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By Hideyuki Ikeda, Shimpei Watanabe, Yuya Saito, Tsukasa Takahashi, Hannah Watson, Erin Johnson Verified, Sean Carter, Yusaku Kumagai, Sebastián Illanes, Masatoshi Saito, Mahesh Choolani, Matthew Kemp, Haruo Usuda, Kantarou Sahara, Noriyoshi Mochii, Michelle Seah, Binny Priya Sesurajan, Shinichi Kawamura
| Nature Verified
Abstract Fetal liver maturation is essential for postnatal metabolic, synthetic, detoxification, and immune function. Disruption of this process by preterm birth contributes to hypoglycemia, impaired detoxification, and immune immaturity. However, the transcriptional programs associated with hepatic maturation during mid-to-late gestation remain incompletely defined. We addressed this gap using a translationally relevant ovine model.
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