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Kaoxue Li

As seen in: MDPI, Royal Society of Chemistry
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Articles

Facile Preparation of High-Performance Polythiophene Derivative and Effect of Torsion Angle Between Thiophene Rings on Electrochromic Color Change

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By Chao Sun, Yiran Li, Kaoxue Li, Qingfu Guo
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Simultaneously GSH-Depleted Bimetallic Cu(II) Complex for Enhanced Chemodynamic Cancer Therapy

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By Shuhua Cao, Yong Gao, Fahui Li, Kaoxue Li
| Royal Society of Chemistry Verified
Simultaneously GSH-Depleted Bimetallic Cu(II) Complex for Enhanced Chemodynamic Cancer Therapy A bimetallic Cu(II) complex as a novel antitumor chemodynamic therapy agent with glutathione (GSH) depletion properties is successfully synthesized and well characterized. In tumor cells, the Cu2+ ions of the complex are reduced to Cu+ by GSH, and then catalyzed by the overexpressed H2O2 to generate highly cytotoxic hydroxyl radical (•OH), which kill cancer cells.
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A Novel Mn-Cu Bimetallic Complex for Enhanced Chemodynamic Therapy with Simultaneous Glutathione Depletion

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By Fahui Li, Shuhua Cao, Kaoxue Li, Xi-Shi Tai
| Royal Society of Chemistry Verified
A Novel Mn-Cu Bimetallic Complex for Enhanced Chemodynamic Therapy with Simultaneous Glutathione Depletion A bimetallic complex, containing Mn (Ⅱ) and Cu (Ⅱ) moieties was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating hydroxyl radical (•OH) via a Mn complex involved Fenton-like reaction, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.
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