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Karen Bannert on Muck Rack

Karen Bannert

As seen in: MDPI
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Articles

Ileocolonic Healing after Small Ileocecal Resection in Mice: NOD2 Deficiency Impairs Anastomotic Healing by Local Mechanisms

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By Johannes Reiner, Karen Bannert, Maria B. Witte, Johannes Saupe
| MDPI
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SNX27 regulates DRA activity and mediates its direct recycling by PDZ-interaction in early endosomes at the apical pole of Caco2 cells

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By Karen Bannert, Peggy Berlin, Johannes Reiner, Heiko Lemcke
| American Physiological Society
Abstract DRA (downregulated in adenoma, SLC26A3) and NHE3 (Na+/H+ exchanger 3, SLC9A3) together mediate intestinal electroneutral NaCl absorption. Both transporters contain PDZ (postsynaptic density 95, disc large, zonula occludens 1) binding motifs and interact with PDZ adaptor proteins regulating their activity and recycling. SNX27 (sorting nexin 27) contains a PDZ domain and is involved in the recycling of cargo proteins including NHE3.
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