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Karen Barthel on Muck Rack

Karen Barthel

As seen in: BioRxiv
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Articles

Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer

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By Jan-Eric Boekenkamp, Kristina Keuper, Stefan Redel, Karen Barthel
| BioRxiv
Abstract Aneuploidy is prevalent in cancer and associates with fitness advantage and poor patient prognosis. Yet, experimentally induced aneuploidy initially leads to adverse effects and impaired proliferation, suggesting that cancer cells must adapt to aneuploidy. We performed in vitro evolution of cells with extra chromosomes and obtained cell lines with improved proliferation and gene expression changes congruent with changes in aneuploid cancers.
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