Karen Duff

Abstract Preservation of synapses is crucial for healthy cognitive ageing, and synapse loss is one of the closest anatomical correlates of cognitive decline in Alzheimer disease, dementia with Lewy bodies and frontotemporal dementia. In these conditions, some synapses seem particularly vulnerable to degeneration whereas others are resilient and remain preserved.

Abstract The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer’s disease (AD). Assembled tau associates with extracellular vesicles (EVs) in the central nervous system of individuals with AD, which is linked to its clearance and prion-like propagation. However, the identities of the assembled tau species and EVs, as well as how they associate, are not known.

Loading metrics Open Access Peer-reviewed Research Article Gustavo A. Rodriguez, Geoffrey M. Barrett, Karen E. Duff , S. Abid Hussaini Gustavo A. Rodriguez, Geoffrey M. Barrett, Karen E. Duff, S. Abid Hussaini Published: August 21, 2020 https://doi.org/10.1371/journal.pbio.3000851 ? This is an uncorrected proof.