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Articles by Karen Kaul
Impact of an integrated monogenic and polygenic risk assessment on Tier-1 conditions in a real-world cohort
Abstract Tier-1 conditions, including breast, colorectal, and prostate cancers and coronary artery disease, have been characterized primarily in patients with hereditary phenotypes but are also common in the general population, partly due to polygenic contributions.
Next-Generation Sequencing-Based Molecular Profiling and Management of Advanced Solid Tumors: A Real-World Experience in a Community-Based Academic Cancer Center
1 Introduction The fields of molecular diagnostics and targeted therapeutics are evolving rapidly, with numerous commercial and academic laboratories providing somatic and germline services on a variety of platforms. Molecular diagnostic studies utilizing next-generation sequencing (NGS) of tumor tissue are now fundamental for diagnosis, prognosis and treatment decision-making in cancer.
Regulation of Laboratory-developed Tests: Scoping the Issue
close Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Disclosures Am J Clin Pathol. 2023;160(3):222-224. Hospital laboratories perform hundreds, even thousands of different tests to support the care of the patients they serve.
How A Coordinated Genome Sequencing Program Can Help Slow The Spread of SARS-Cov-2 Variants
Over a year after the World Health Organization declared the COVID-19 to be a global pandemic, the US should be leading global diagnostic efforts for COVID-19; instead, we have lagged in our response to dangerous viral mutations and variants. The US is home to many of the world’s leading clinical laboratories, test manufacturers, and most prominent thought leaders, but we have trailed many developed countries in ramping up diagnosis and characterization of SARS-CoV-2.
Over regulation of laboratories threatens promise of precision medicine
Healthcare currently stands at an inflection point that the industry has never before faced. The human genome has been sequenced and we are seeing an explosion of knowledge and technology applicable to patient care – this is the promise of precision medicine. To realize that promise, we need to integrate new knowledge and technology into the clinic so that precision medicine can become an innovative reality—but continue to maintain a high level of accuracy and safety.
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