Karima Mokhtari on Muck Rack

Karima Mokhtari

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Articles

Clinical responses to trastuzumab deruxtecan in molecularly defined ependymoma

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By L. Castro, Yi-Chien Wu, Jia-Ren Lin, Maria-Joao Santiago-Ribeiro, Alice Laurenge, Alexandre Carpentier, Shannon Coy, Nancy Lin, Keith L. Ligon, Mehdi Touat, Sandro Santagata, Karima Mokhtari
| Nature Verified
Abstract Despite evidence that antibody drug conjugates (ADCs) are active in brain metastases, their role in primary central nervous system (CNS) tumors remains unclear. We report two adults with molecularly defined ependymoma – a MYCN-amplified spinal tumor with intracranial dissemination and a supratentorial ZFTA-RELA-fused tumor with multiple recurrences – who demonstrated radiographic response and/or durable clinical and metabolic stability with trastuzumab deruxtecan (T-DXd).
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