Karina Salgado

Abstract Background: Vanishing bile duct syndrome (VBDS) is an uncommon but clinically important form of cholestatic liver injury, defined by progressive loss of intrahepatic bile ducts and persistent cholestasis. Drug-induced liver injury is one of its recognized causes, and antibiotics are among the most frequently implicated agents. Cephalosporin-associated VBDS remains rare, and cefadroxil has been only exceptionally considered in this context.