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Karisma Nagarkatti on Muck Rack

Karisma Nagarkatti

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Articles

Methods for randomized, blinded, controlled evaluation of putative disease interventions in multilaboratory, preclinical assessment networks - Lab Animal

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By Jessica Lamb, Karisma Nagarkatti, Márcio Diniz, Ryan P Cabeen, Monica V. Estrada, Mónica Valeria Estrada, Karen Crawford, André Rogatko, Sungjin Kim, Cenk Ayata, David C Hess, Mohammad Khan, Rakesh Patel, Mariia Kumskova, Enrique C. Leira, Anil K Chauhan, Patrick D. Lyden
| Nature Verified
Abstract Science faces a reproducibility crisis, and public trust in science declines when large clinical trials, which had been qualified by promising preclinical studies, fail. While some clinical trial designs may have been inadequate, preclinical assessments of disease interventions might have lacked key elements of rigor such as treatment concealment, randomization, blinded outcomes, prespecified and adequate sample sizes, and models including comorbidities.
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