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Kark Schaller

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Articles

Perioperative myeloid cell remodeling shapes CAR-T cell efficacy in glioblastoma

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By Luis Cantero, Ali Ghasemi, Eliana Marinari, Julie Pernot, Doron Merkler, Kristof Egervari, Philippe Bijlenga, Andrea Bartoli, Shahan Momjian, Mikael J. Pittet, Valérie Dutoit, Denis Migliorini, Martin Pedard, Caterina Mollica, Suzel Davanture, Valérie Widmer, Kark Schaller
| Nature Verified
Abstract Glioblastoma (GBM) is characterized by a profoundly immunosuppressive tumor microenvironment (TME) that constrains the efficacy of chimeric antigen receptor (CAR)-T cell therapy. Here, we show that surgical resection in both male mice and human GBM ex vivo induces a rapid and sustained remodeling of the TME, marked by upregulation of TREM2 in myeloid cells followed by emergence of T cell exhaustion-like phenotypes.
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