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Karl Barry Sharpless on Muck Rack

Karl Barry Sharpless

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Articles

Click-based determination of accumulation of molecules in Escherichia coli - Nature Communications

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By Zichen Liu, Shasha Feng, Mahendra D. Chordia, mohammad Gh, Jiajia Dong, Wonpil Im, Karl Barry Sharpless
| Nature Verified
Abstract Gram-negative bacterial pathogens pose a significant challenge in drug development because their outer membranes hinder the permeation of small molecules. The lack of widely adoptable methods for measuring the cytosolic accumulation of compounds in bacterial cells further hinders drug discovery efforts.
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