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Live30 webinars are thirty-minute presentations designed to update you on the latest innovations, applications, and data in a fast yet interactive format. The percentage of full and empty capsids in an AAV drug product can significantly affect therapeutic benefit vs immunogenicity risk. Many challenges persist in viral vector manufacturing that can result in the gene of interest not being appropriately packaged in the capsid and therefore not delivered to the patient.
Highlights • Cryo-EM structure of the human spliceosomal C complex at 3.4 Å core resolution • Localization and likely function of novel C-specific proteins in human C complexes • Metazoan-specific proteins stabilize key protein and RNA regions in human C complexes • The timing of RNP rearrangements differs in human and yeast C/C ∗ complexes Summary Human spliceosomes contain numerous proteins absent in yeast, whose functions remain largely unknown.
Abstract The U2 small nuclear ribonucleoprotein (snRNP) has an essential role in the selection of the precursor mRNA branch-site adenosine, the nucleophile for the first step of splicing1. Stable addition of U2 during early spliceosome formation requires the DEAD-box ATPase PRP52,3,4,5,6,7.
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