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Karl Xaver Knaup on Muck Rack

Karl Xaver Knaup

As seen in: Nature, medRxiv
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Articles

Characterization of the neoprotein MUC1-fs in patient-derived cells with ADTKD-MUC1

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By Karl Xaver Knaup, Karen Schneider, Hannah Schwarz
| medRxiv
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. Yes The details of the IRB/oversight body that provided approval or exemption for the research described are given below: Ethics committee of the Friedrich-Alexander University Erlangen-Nuernberg, Germany, gave ethical approval for this work.
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Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease

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By Xianyi Meng, Bettina Grötsch, Yubin Luo, Karl Xaver Knaup
| Nature Verified
To investigate the role of HIFs in B cells, the expression of HIF-1? and HIF-2? was determined in C57BL/6 WT splenic B cells stimulated with lipopolysaccharide (LPS) (10??g/ml) or anti-IgM (10??g/ml). Even under normoxic conditions, Hif1a mRNA expression is induced in B cells stimulated with LPS or anti-IgM (Fig. 1a), whereas the expression of Hif2a is almost undetectable and remains unchanged when analyzed in fold change (Fig. 1a). Accordingly, HIF-2? protein is hardly detectable, whereas HIF-1?
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