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Karoline Barros Waitman on Muck Rack

Karoline Barros Waitman

As seen in: BioRxiv
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Articles

Dona Flor and her two husbands: Discovery of novel HDAC6/AKT2 inhibitors for myeloid cancer treatment

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By Holli-Joi Martin, Rodolpho Braga, Cleber Melo-Filho, Karoline Barros Waitman
| BioRxiv
Abstract Hematological cancer treatment with hybrid kinase/HDAC inhibitors is a novel strategy to overcome the challenge of acquired resistance to drugs. We collected IC50 datasets from the ChEMBL database for 13 cancer cell lines (72 h cytotoxicity, measured by MTT), known inhibitors for 38 kinases, and 10 HDACs isoforms, that we identified by target fishing and literature review.
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