Karoline Horgmo Jæger

Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Jæger KH, Tveito A (2026) Accurate computation of ionic concentrations in the synaptic cleft requires the full Poisson–Nernst–Planck (PNP) equations. PLoS Comput Biol 22(5): e1014341.

Abstract Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer new opportunities to study cardiac dynamics and drug responses. High-throughput platforms often rely on extracellular potential (EP) recordings, making signal strength critical for analysis. To examine how stimulation protocols shape EPs, we used a computational model of hiPSC-CMs cultured in a well geometry and compared extracellular recordings under uniform and localized stimulation.

Abstract Excitable cells are commonly studied via the extracellular potentials (EPs) they generate, which underlie signals in electroencephalography (EEG), electrocardiography (ECG), and multielectrode array (MEA) recordings. However, some excitable systems produce little or no detectable EPs, for reasons that remain poorly understood.