Karteek Kunala on Muck Rack

Karteek Kunala

As seen in: Retina Specialist
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Articles

Beyond structural retinal imaging: Adaptive optics fluorescence lifetime ophthalmoscopy (AOFLIO)

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By Karteek Kunala, Jennifer Hunter
| Retina Specialist
Take-home points Fluorescence lifetime imaging ophthalmoscopy provides a label-free approach to observe functional and molecular changes in the eye with age and disease. It has the potential for early disease detection in clinical practice. Combining adaptive optics and fluorescence lifetime imaging allows visualization of cellular variations. Bios Dr. Kunala is a research engineer in the department of ophthalmology at Stanford Medicine in Palo Alto, California.
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Foveal RGCs develop altered calcium dynamics weeks after photoreceptor ablation

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By Zhengyang Xu, Karteek Kunala, Peter Murphy, Teresa Puthussery
| biorxiv.org
Abstract Physiological changes in retinal ganglion cells (RGCs) have been reported in rodent models of photoreceptor (PR) loss but this has not been investigated in primates. By expressing both a calcium indicator (GCaMP6s) and an optogenetic actuator (ChrimsonR) in foveal RGCs of the macaque, we reactivated RGCs in vivo and assessed their response in the weeks and years following PR loss.
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Foveal RGCs develop abnormal calcium dynamics weeks after photoreceptor ablation

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By Zhengyang Xu, Peter Murphy, Teresa Puthussery, Karteek Kunala
| biorxiv.org
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