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Karuna Devi Irungbam on Muck Rack

Karuna Devi Irungbam

As seen in: BioRxiv
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Articles

Cholesterol-Dependent Conformational Modulation and Binding Hotspots of P2RX7: Insights from Molecular Dynamics Simulations and Structural Analyses

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By Mukesh Kumar, Jayant G. Joshi, Karuna Devi Irungbam
| dx.doi.org
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Insights from Molecular Docking and Dynamics Simulations of P2RX7-š¯›¼Syn Complex

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By Kanchan Singh, Jayant G. Joshi, Shreya Sharma, Karuna Devi Irungbam
| BioRxiv
Abstract Alpha-synucleinopathies, characterized by extracellular alpha-synuclein (aSyn) accumulation and aggregation, have been linked to neurological disorders including Parkinson disease (PD) and multiple system atrophy (MSA). aSyn interacts with membrane proteins, phospholipids, and cholesterol, leading to membrane damage and inflammation.
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