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Karyn L. Wilde on Muck Rack

Karyn L. Wilde

As seen in: Nature, ANSTO
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Articles

Landmark achievement opens pathway for treatment of drug-resistant tuberculosis

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By Ivanhoe Leung, Ashish Sethi, Karyn L. Wilde, Brooke X. C. Kwai
| ANSTO
Published on the 30th April 2026 by ANSTO Staff Share to FacebookShare to BlueskyShare to LinkedIn Key Points Research revealed a hidden mechanism that activates a key enzyme ICL2 in Mycobacterium tuberculosis Study opens a target pathway to treat drug-resistant TB Multiple capabilities at the Australian Synchrotron and the National Deuteration Facility were used in the investigation ANSTO has contributed to a recent publication in Nature Communications Biology that represents a landmark...
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Structural basis underlying the synergism of NADase and SLO during group A Streptococcus infection - Communications Biology

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By Michal Hammel, Andrew E. Whitten, Chuan Chiang-Ni, Toshiya Senda, Karyn L. Wilde
| Nature Verified
Abstract Group A Streptococcus (GAS) is a strict human pathogen possessing a unique pathogenic trait that utilizes the cooperative activity of NAD+-glycohydrolase (NADase) and Streptolysin O (SLO) to enhance its virulence. How NADase interacts with SLO to synergistically promote GAS cytotoxicity and intracellular survival is a long-standing question.
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