Kasandra Albarran

Abstract We explored the feasibility of utilizing optical coherence tomography angiography (OCTA) device in a peri-operative setting to assess the perfusion status of the retinal microcirculation by perturbating a quantitative macrocirculatory target - mean arterial pressure (MAP), and by extension, the cerebrovascular microcirculation. Using a porcine model, we were able to induce hypercarbia, epinephrine-led resuscitation, and hemorrhage followed by autologous re-transfusion scenarios.

Abstract Objective: Quantifying physiological flow dynamics in the brain's microvasculature is vital for effective resuscitation management. Traditional resuscitation approaches rely on macrocirculatory flow targets, which often poorly correlate with cerebral microcirculatory flow. Our observational pilot study investigates the feasibility of using optical coherence tomography angiography (OCTA) to image retinal microcirculatory blood flow in the immediate perioperative setting.