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Kasha Mansour

As seen in: PLOS Biology, BioRxiv
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Articles

Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior

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By Sarfraz Shafiq, Alireza Ghahramani, Kasha Mansour, Miguel Pena-Ortiz
| PLOS Biology Verified
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Shafiq S, Ghahramani A, Mansour K, Pena-Ortiz M, Sunstrum JK, Pavlovic M, et al. (2025) Microglial deficiency in the ATRX chromatin remodeler elicits a viral mimicry immune response that impacts neuronal function and behavior. PLoS Biol 23(9): e3002659.
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Viral mimicry and memory deficits upon microglial deletion of ATRX

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By Sarfraz Shafiq, Alireza Ghahramani, Kasha Mansour, Miguel Pena-Ortiz
| BioRxiv
Abstract The importance of chromatin-mediated processes in neurodevelopmental and intellectual disability disorders is well recognised. However, how chromatin dysregulation in glial cells impacts cognitive abilities is less well understood. Here, we demonstrate that targeted loss of the ATRX chromatin remodeler in microglia alters chromatin accessibility profiles, leading to the de-repression of endogenous retroelements, triggering viral mimicry.
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