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Kasra Alizadeh on Muck Rack

Kasra Alizadeh

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Articles

Rewiring the ribosome to translate proteins encoded in its own RNA

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By Dorota Klepacki, Nora Vázquez-Laslop, Alexander S. Mankin, Kasra Alizadeh
| Nature Verified
Abstract Cellular protein synthesis relies on random encounters between ribosomes and mRNAs, limiting optimization of the translation machinery for production of a single protein—a key need in biotechnology. One potential solution is integrating the protein-coding sequence into the ribosome itself, thereby committing the ribosome to synthesis of a single polypeptide.
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