Katarína Mikušová on Muck Rack

Katarína Mikušová

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Articles

Structural basis of lipid-linked galactan export by the mycobacterial ABC transporter Wzm-Wzt

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By Alisa A. Garaeva, Viktória Fabiánová, Karin Savková, Xiaochao Xue, Todd L. Lowary, Markus Seeger, Stanislav Huszár, Katarína Mikušová
| Nature
Abstract Mycobacteria, including Mycobacterium tuberculosis, possess a unique cell envelope containing arabinogalactan, a heteropolysaccharide critical for cell wall integrity and target of several tuberculosis drugs. The cytosolic precursor of arabinogalactan, lipid-linked galactan (LLG), is translocated across the plasma membrane by the essential ABC transporter Wzm-Wzt through a molecular mechanism that is poorly understood.
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