Katharine Barrett

Abstract Targeted protein degradation is a powerful pharmacological strategy that harnesses the ubiquitin proteasome system to eliminate disease-relevant proteins, including otherwise undruggable proteins1. Here we report an unbiased and broadly applicable platform for the systematic discovery of molecular glues across diverse E3 ligases. Using multiplexed mass spectrometry-based chemical screening, we identified M12, a molecular glue that reprogrammes the E3 ligase DCAF11 to degrade DDX18.

Today I would like to share with you two of my new favorite things… Downton Abbey and an Apricot Scones Recipe. I have long been a fan of British television, having seen every episode of ‘Ballykissangel’, ‘Sherlock Holmes’ and ‘Poirot’ several times over. Somehow, I was a bit late to catch on to ‘Downton Abbey’. It might have something to do with the 30 plus episodes of Masterpiece Theatre on my DVR, waiting to be watched.

“Oh! I know this one! That means sun!” shouts McKenna, a first-grader at Kate Furbish Elementary School, pointing to a brightly-painted sun in a picture book. She remembers this word from the last time I read to her in Spanish; the visual helps trigger her memory. “That’s how to say it in Portuguese, too!” her classmate Kevin remarks. McKenna is thrilled to learn she now knows this word in three languages.