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Katherine S. Barker on Muck Rack

Katherine S. Barker

As seen in: BioRxiv
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Articles

Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in Candida auris, Candida albicans, Candida parapsilosis, and Candida glabrata (Nakaseomyces glabratus)

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By Katherine S. Barker, Hoja P. Patterson, Joachim Morschhäuser, Christina A. Cuomo
| BioRxiv
Abstract The fungal pathogen Candida auris is of global concern due to high levels of multidrug resistance and its propensity to cause infectious outbreaks. Over 90% of isolates are resistant to fluconazole, the most commonly prescribed antifungal world-wide. Fluconazole resistance is multifactorial with many isolates carrying mutations in the gene encoding the transcriptional regulator Tac1B, leading to increased expression of the gene encoding the ATP Binding Cassette (ABC) transporter Cdr1.
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Relative contributions of the ERG11VF125AL and MRR1AN647T mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates

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By Katherine S. Barker, Qing Zhang, Tracy L Peters, Jeffrey M. Rybak
| BioRxiv
Abstract Objectives: Candidozyma (Candida) auris is an emerging fungal pathogen of global concern that often exhibits multi-drug resistance. Over 90% of isolates are resistant to fluconazole. Of the six described clades of C.
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Mutations in TAC1B drive CDR1 and MDR1 expression and azole resistance in C. auris

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By Katherine S. Barker, Darian J. Santana, Qing Zhang, Tracy L Peters
| BioRxiv
Abstract Objective: Candida auris has emerged as a fungal pathogen of particular concern owing in part to its propensity to exhibit antifungal resistance, especially to the commonly prescribed antifungal fluconazole. In this work we aimed to determine how mutations in the transcription factor gene TAC1B, which are common among resistant isolates and confer fluconazole resistance, exert this effect.
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