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Evaluation of Necrosis as a Diagnostic and Prognostic Indicator in Adrenocortical Carcinoma
Research Letter September 8, 2021 JAMA Surg. 2021;156(12):1173-1174. doi:10.1001/jamasurg.2021.3646 Adrenocortical carcinoma (ACC) is rare and has a poor prognosis. In part because of its rarity, the pathological diagnosis of ACC is based on unstandardized criteria that are difficult to apply. Histologic variants further complicate the differentiation of benign and malignant disease in the adrenal gland.1 Scoring systems and algorithms for the pathological diagnosis of ACC have been proposed.
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