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Kathryn E Holt on Muck Rack

Kathryn E Holt

As seen in: Nature, Journal of Antimicrobial Chemotherapy, PLOS, BMJ Open, Gut Journal, Genome Biology, Genome Medicine, BioRxiv, The Lancet, Microbiology Research and
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Articles

Exploring the IS-capades of Klebsiella pneumoniae: insertion sequences drive metabolic loss in obscure sub-lineages

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By Ben Vezina, Claire White, Helena B Cooper, Kathryn E Holt
| Microbiology Research
Article metrics loading... /content/journal/mgen/10.1099/mgen.0.001612 Metrics Download as PowerPoint /deliver/fulltext/mgen/12/1/mgen001612.html?itemId=/content/journal/mgen/10.1099/mgen.0.001612&mimeType=html&fmt=ahah References Vezina B, White C, Cooper HB, Holt KE, Hawkey J et al. Analysis code for Exploring the IS-capades of Klebsiella pneumoniae: insertion sequences drive metabolic loss in obscure sub-lineages. Figshare 2026 [View Article] [Google Scholar] Wyres KL, Lam MMC, Holt KE.
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Microbial genomics for antimicrobial resistance ecology and action - Nature Reviews Genetics

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By Kathryn E Holt
| Nature Verified
The scale-up of microbial genomics has seen notable advances in understanding the dynamics of antimicrobial resistance (AMR) across species, environments and ecosystems. To gain meaningful insights that can ultimately inform AMR control strategies, stronger analytical frameworks are needed that integrate data across temporal, spatial and molecular scales.
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The characterization of Klebsiella pneumoniae associated with neonatal sepsis in low- and middle-income countries to inform vaccine design - Communications Biology

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By Francesca Nonne, Martina Carducci, Stephen Baker, Kathryn E Holt, Kelly L. Wyres, Neil Ravenscroft, Carlo Giannelli, Casey Zakroff, Thomas D. Stanton
| Nature Verified
Abstract Klebsiella pneumoniae is the leading cause of neonatal sepsis, strongly associated to antimicrobial resistance, with no vaccine available. K-antigens (KAg) have been identified as potential targets, but their diversity makes vaccine development challenging. Alternatively, the use of subcapsular O-antigens (OAg) raises questions about antibodies accessibility.
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