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Articles

Lipid-manager autophagy proteins ATG2 and ATG9 regulate extracellular vesicle secretion via amphisome biogenesis and cell lipidome modulation

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By Asmita Singh, Dylan Johnson, Jeffrey Kuhn, Katina Johnson, Jason Williams, Kedar Sharma, Jadranka Loncarek, Mario J. Borgnia, Carlos M. Guardia, Ricardo Vancini, Deloris Sutton
| Nature Verified
Abstract Autophagy intersects with endocytic trafficking to regulate extracellular vesicle (EV) biogenesis, but how upstream lipid-handling autophagy proteins influence this crosstalk is unclear. Here we show that the autophagy lipid-supply proteins ATG9A and ATG2A/B restrain small EV (sEV) secretion by promoting amphisome formation and controlling cellular lipid composition.
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