Katka Franke on Muck Rack

Katka Franke

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Articles

Glutaminyl cyclase is an enzymatic modifier of the CD47- SIRPα axis and a target for cancer immunotherapy

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By Matthijs Raaben, Mireille Toebes, Arianne M. Brandsma, Katka Franke
| Nature Verified
Abstract Cancer cells can evade immune surveillance through the expression of inhibitory ligands that bind their cognate receptors on immune effector cells. Expression of programmed death ligand 1 in tumor microenvironments is a major immune checkpoint for tumor-specific T cell responses as it binds to programmed cell death protein-1 on activated and dysfunctional T cells1.
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