Katrin Gutsche on Muck Rack

Katrin Gutsche

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Unhooking the Hook: Optimization of the Aurora A Targeting PROTAC JB170 to CCT400028, an In Vitro Degrader Chemical Probe

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By Jack A. O’Hanlon, Juliane Müller, Nihar Ranjan Prusty, Katrin Gutsche
| dx.doi.org
Introduction Click to copy section linkSection link copied! The Aurora family of serine/threonine kinases (Aurora A, B, and C) play important roles in cell cycle progression and the regulation of mitosis through their catalytic activity. Aurora A and B are ubiquitously expressed and have distinct roles during different phases of mitosis, whereas Aurora C is primarily expressed in the testes. (1−3) Aurora A regulates centrosome maturation before mitotic entry and mitotic spindle assembly.
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