Kayleigh Bozon on Muck Rack

Kayleigh Bozon

As seen in: eLife
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Articles

Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

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By Kayleigh Bozon, Hartmut Cuny, Delicia Z. Sheng, Alena Sipka
| eLife
eLife Assessment NAD deficiency perturbs embryonic development resulting in multiple congenital malformations, collectively termed Congenital NAD Deficiency Disorder (CNDD). The authors report fundamental findings demonstrating that extra-embryonic visceral yolk sac endoderm is critical for NAD de novo synthesis during early organogenesis and perturbations of this pathway may underlie CNDD.
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Impaired yolk sac NAD metabolism disrupts murine embryogenesis with relevance to human birth defects

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By Hartmut Cuny, Delicia Z. Sheng, Paul Young, Kayleigh Bozon
| biorxiv.org
Abstract Severe congenital malformations are a frequent cause of premature death and morbidity in children worldwide. Malformations can originate from numerous genetic or non-genetic factors but in most cases the underlying causes are unknown.
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