Kayyali chair

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, , & (2019). Lipoprotein drug delivery vehicles for cancer: Rationale and reason. International Journal of Molecular Sciences, 20, 6327. 2, , , , & (2014). Validated UHPLC-DAD method for quantification of cholesteryl-succinyl-5-fluorouracil conjugate. Bulgarian Chemical Communications, 46, 806. 3, & (2020). The efficacy of cholesterol-based carriers in drug delivery. Molecules (Basel, Switzerland), 25, 4330.

1 Introduction Lung cancer is one of the world’s most life-threatening diseases. In 2023, smoking cigarettes will directly cause around 81% lung cancer deaths, with second-hand smoke contributing to an additional 3,560 of the 127,070 fatalities Siegel et al. (1). There are two primary categories of lung nodules: benign and malignant. Lung nodules that are benign remain firmly in their original position and do not spread to other bodily areas Heuvelmans et al. (2).

Loading metrics Open Access Peer-reviewed Research Article Awwad Radwan , Gamal M. Mahrous Awwad Radwan, Gamal M. Mahrous Published: June 5, 2020 https://doi.org/10.1371/journal.pone.0234215 Figures Abstract Bacterial histidine kinases (HKs) are considered attractive drug targets because of their ability to govern adaptive responses coupled with their ubiquity. There are several classes of HK inhibitors; however, they suffer from drug resistance, poor bioavailability, and a lack of selectivity.