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Kazutaka Ito on Muck Rack

Kazutaka Ito

Verified
London
As seen in: Asahi Shimbun, Nature
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Articles

Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography - Nature Chemistry

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By Alexander Wolff, Eriko Nango, Aaron Brewster, Minoru Kubo, Benjamin A. Barad, Kazutaka Ito Verified, Asmit Bhowmick, Sergio Carbajo, James M. Holton, Rie Tanaka, Raymond G Sierra, Kensuke Tono, So Iwata, Nicholas K. Sauter, James Fraser
| Nature Verified
Abstract Understanding and controlling protein motion at atomic resolution is a hallmark challenge for structural biologists and protein engineers because conformational dynamics are essential for complex functions such as enzyme catalysis and allosteric regulation. Time-resolved crystallography offers a window into protein motions, yet without a universal perturbation to initiate conformational changes the method has been limited in scope.
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