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Kazutake Tsujikawa on Muck Rack

Kazutake Tsujikawa

As seen in: Nature, Royal Society of Chemistry
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Articles

Shotgun metagenomic sequencing of serum extracellular vesicle-derived DNA enables microbial profiling in urothelial carcinoma

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By Toshihiro Uemura, Atsunari Kawashima, Kentaro Jingushi, Daisuke Motooka, Takuro Saito, Shunsuke Inoguchi, Nesrine Sassi, Yuki Horibe, Tomohiro Kanaki, Yutong Liu, Masaru Tani, Akihiro Yoshimura, Toshiki Oka, Yohei Okuda, Gaku Yamamichi, Yu Ishizuya, Takuji Hayashi, Yoshiyuki YAMAMOTO, Taigo Kato, Koji Hatano, Kazutake Tsujikawa, Hisashi Wada, Norio Nonomura, Akinaru Yamamoto
| Nature Verified
Abstract Shotgun metagenomic sequencing provides more detailed microbial information than 16 S rRNA sequencing but requires higher cost and larger sample volumes. We evaluated whether shotgun metagenomic sequencing could detect bacterial DNA in serum extracellular vesicles. Serum samples from 72 patients with urothelial carcinoma (surgery, n = 45; immune checkpoint inhibitor therapy, n = 27) and 20 healthy controls were analyzed; all had been previously examined using 16 S rRNA sequencing.
Open in Who Shared Issue with article?

Muscle regeneration is disrupted by cancer cachexia without loss of muscle stem cell potential

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By Masashi Tachibana, Shoya Inaba, Atsushi Hinohara, Kazutake Tsujikawa
| PLOS
As previously mentioned, weakness and instability of the sarcolemma have been reported by independent research groups [ 3 , 5 , 21 ]. In both muscles of human gastric cancer patients and mouse of a mouse cancer cachexia model, Pax7 and MyoD mRNA/protein levels were upregulated [ 4 , 22 ]. Because activated MuSCs are positive for both Pax7 and MyoD [ 23 ], these results suggest that the MuSC may be in an activated state. In fact, Penna et al.
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