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Ke Jia Khoo on Muck Rack

Ke Jia Khoo

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Articles

ENO2 sustains cancer stemness and metastatic competence through a phosphoenolpyruvate-dependent metabolic axis in triple-negative breast cancer

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By Cing-Hong Wang, Ru-Tsun Mai, Chi-Feng Hung, Cheng-Kuang Yang, Meng-Ju Wu, Chi-Hong Chao, Ke Jia Khoo
| Nature Verified
Abstract Enolase 2 (ENO2) is a neuron-specific glycolytic enzyme whose expression is elevated in aggressive breast cancers, yet its enzymatic and biological contributions to triple-negative breast cancer (TNBC) progression remain incompletely defined. Here, we demonstrate that ENO2 sustains cancer stem cell (CSC) properties and metastatic competence through a phosphoenolpyruvate (PEP)-dependent metabolic axis.
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