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Keir Barnbrook on Muck Rack

Keir Barnbrook

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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen - Nature Communications

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By Andrew Poole, Vijaykumar Karuppiah, Tomasz Dobrzycki, Annabelle Hartt, Keir Barnbrook, Gregory D. Plowman, Andrew D. Whale
| Nature Verified
Abstract Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and development of an affinity-enhanced T cell receptor (TCR) that recognizes a peptide derived from the most common KRAS mutant, KRASG12D, presented in the context of HLA-A*11:01.
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