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Keirah E. Bartlett on Muck Rack

Keirah E. Bartlett

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Articles

Snake venom metalloproteinases are predominantly responsible for the cytotoxic effects of certain African viper venoms

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By Keirah E. Bartlett, Adam Westhorpe, Mark Wilkinson Verified, Nicholas R. Casewell
| BioRxiv
Abstract Snakebite envenoming is a neglected tropical disease that causes substantial mortality and morbidity globally. The puff adder (Bitis arietans) and saw-scaled viper (Echis romani) have cytotoxic venoms that cause permanent injury via tissue-destructive dermonecrosis around the bite site. Identification of cytotoxic toxins within these venoms will allow development of targeted treatments, such as small molecule inhibitors or monoclonal antibodies to prevent snakebite morbidity.
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Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms - Nature Communications

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By Steven Hall, Sean A Rasmussen, Charlotte Dawson, Keirah E. Bartlett, Jeroen Kool, José Gutiérrez, José María Gutiérrez Verified
| Nature Verified
Abstract Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms. Repurposed small molecule drugs that inhibit specific snake venom toxins show considerable promise for tackling this neglected tropical disease.
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Dermonecrosis caused by spitting cobra snakebite is the result of toxin potentiation and is prevented by the repurposed drug varespladib

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By Keirah E. Bartlett, Charlotte Dawson, Sean A Rasmussen, Edouard Crittenden
| BioRxiv
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