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Articles by Keisuke Ishihara
The endoplasmic reticulum connects to the nucleus by constricted junctions that mature after open mitosis in mammalian cells
Abstract The endoplasmic reticulum (ER) is physically connected to the nucleus by junctions with the outer membrane of the nuclear envelope (NE). The ER-NE junctions are essential for supplying the NE with lipids and proteins synthesized in the ER. However, little is known about the structure of these ER-NE junctions.
Neural tube organoids self-organise floorplate through BMP-mediated cluster competition
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Clonal neural tube organoids self-organise floorplate through BMP-mediated cluster competition
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The junctions connecting the endoplasmic reticulum to the nuclear envelope are constricted and remodelled during the cell cycle
New Results doi: https://doi.org/10.1101/2023.01.31.526419 Abstract The endoplasmic reticulum (ER) is physically connected to the cell nucleus via junctions with the nuclear envelope (NE). These ER-NE junctions are essential for supplying the NE with lipids and transmembrane proteins that are synthesized in the ER. Despite the important role of ER-NE junctions, their biogenesis, architecture and maintenance across the cell cycle has remained elusive.
Topological morphogenesis of neuroepithelial organoids - Nature Physics
Abstract Animal organs exhibit complex topologies involving cavities and tubular networks, which underlie their form and function1,2,3. However, how topology emerges during the development of organ shape, or morphogenesis, remains elusive. Here we combine tissue reconstitution and quantitative microscopy to show that tissue topology and shape is governed by two distinct modes of topological transitions4,5.
Force generation by protein-DNA co-condensation
Abstract Interactions between liquids and surfaces generate forces1,2 that are crucial for many processes in biology, physics and engineering, including the motion of insects on the surface of water3, modulation of the material properties of spider silk4 and self-assembly of microstructures5. Recent studies have shown that cells assemble biomolecular condensates via phase separation6.
Physical basis of large microtubule aster growth
Physical basis of large microtubule aster growth ACCEPTED MANUSCRIPTPhysical basis of large microtubule aster growth Keisuke Ishihara Kirill S Korolev Timothy J Mitchison Center for Systems Biology Dresden, Germany; Boston University, United States; Harvard Medical School, United States Published November 28, 2016Cite as eLife 2016;10.7554/eLife.19145
Physical basis of large microtubule aster growth
Physical basis of large microtubule aster growth Keisuke Ishihara, Kirill S Korolev, Timothy J Mitchison bioRxiv 055939; doi: http://dx.doi.org/10.1101/055939
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